OUR INGREDIENTS

🌿 Standardized Rheum rhaponticum root extract (Siberian Rhubarb)
Rheum rhaponticum root extract is characterized by selective action on the estrogen receptor beta (ERβ), offering a targeted, non-hormonal approach to managing perimenopausal symptoms. It has been evaluated in randomized, double-blind, placebo-controlled studies in women with climacteric symptoms, where a statistically significant reduction in the total MRS/MRS II score was recorded within 12 weeks compared to placebo. Particularly impressive was the improvement in hot flashes, both in their frequency and severity, with some studies showing clinically visible improvement as early as the first 4 weeks of use.
Additionally, significant improvement was reported in psychological parameters, including a reduction in anxiety based on the Hamilton Anxiety Scale. In long-term follow-up for up to 96 weeks, the reduction in symptoms was maintained, with a further decrease in the frequency of hot flashes. These data reinforce the position of Siberian rhubarb as a clinically studied, non-hormonal option for supporting vasomotor and related symptoms of perimenopause, with documented duration of action and a stable safety profile.

🌿 Black Cohosh (Cimicifuga racemosa)
Black Cohosh is one of the most studied herbal extracts for managing menopausal symptoms. Its action appears to be primarily related to serotonergic mechanisms and the regulation of hypothalamic thermoregulatory centers, which are directly involved in the occurrence of hot flashes and night sweats.
According to a recent systematic review of 22 randomized clinical studies, which included more than 2,300 women, the administration of standardized Black Cohosh extracts was associated with a statistically significant reduction in overall menopausal symptoms, with particular emphasis on vasomotor symptoms compared to placebo. These data reinforce its position as a scientifically proven, non-hormonal option that fundamentally aims to improve the daily life and quality of life of modern women during menopause.

🌿 Soy Isoflavones
Soy isoflavones are among the most classic and clinically studied phytonutrients for supporting women during perimenopause and menopause. Recent meta-analyses in perimenopausal women showed a statistically significant overall improvement in menopausal symptoms compared to placebo, with a more pronounced effect on headaches, psychosocial symptoms, palpitations, and depression indicators. The data support a mild but clinically measurable contribution, particularly to the psycho-emotional aspect of this transitional phase, where hormonal fluctuation affects mood and overall quality of life.
Additionally, an improvement in lipid profile has been documented, with a reduction in total cholesterol and a slight increase in HDL, as well as favorable trends in bone metabolism markers. In terms of safety, a recent meta-analysis of randomized studies in postmenopausal women showed that isoflavones did not increase estrogenicity markers, such as endometrial thickness, compared to placebo. This element reinforces their image as selective estrogen receptor modulators (SERM-like action) rather than hormone replacement, making them a balanced, non-hormonal option for modern women.

🌿 Chaste Tree (Vitex agnus-castus)
Vitex agnus-castus is one of the most time-tested and clinically evaluated herbal extracts for female hormonal balance, with data in both perimenopause and menopause. In randomized, double-blind, placebo-controlled studies, its administration was associated with a statistically significant reduction in the total menopausal symptoms score (GCS), with particular improvement in anxiety indicators and vasomotor symptoms, such as hot flashes. In a second randomized study, Vitex led to a substantial reduction in both the frequency and intensity of hot flashes, with an overall improvement in GCS reaching 45–55%.
During perimenopause, where hormonal instability, shorter or anovulatory cycles, and progesterone fluctuations are common, many women experience more intense or unpredictable PMS-like symptoms. In this context, the documentation of Vitex in premenstrual syndrome becomes particularly important: in a meta-analysis of double-blind RCTs, women who received Vitex were about 2.6 times more likely to achieve remission of PMS symptoms compared to placebo. Furthermore, in a randomized, double-blind study in women with cyclic mastalgia, taking the extract for three cycles led to a measurable reduction in pain intensity (VAS). These data reinforce its role as a targeted, non-hormonal option for symptoms related to cyclical hormonal fluctuations, which often intensify during perimenopause.

Vitamin D3
Vitamin D3 is not merely a "bone vitamin" but a hormonally active substance with receptors in almost every tissue of the body. Adequate replenishment in individuals with low levels has been associated with improved immune system function, support for a normal anti-inflammatory response, and enhanced muscle strength and functionality. Concurrently, correction of deficiency has been linked to improvements in mood, energy levels, and overall well-being — particularly when initial levels are low.
Vitamin D sufficiency has also been associated with better metabolic regulation, normal cardiovascular function, and support for glycemic balance. Epidemiological and clinical data indicate that maintaining 25-hydroxyvitamin D levels above 30 ng/mL (75 nmol/L) is linked to a significant reduction in the total disease burden for eight of the ten leading causes of death, including cardiovascular disease, cancer, stroke, diabetes mellitus, chronic kidney disease, and neurodegenerative disorders. Although large randomized studies show that supplementation in already sufficient populations is not a "miracle" intervention, replenishing deficiency remains fundamental for the proper functioning of multiple systems and for maintaining a strong foundation for long-term health.

Vitamin K2
Vitamin K2 in the MK-7 form acts as a regulator of proper calcium distribution. By activating key proteins, such as osteocalcin and MGP (Matrix Gla Protein), it supports calcium incorporation into bones and the maintenance of vascular elasticity. The MK-7 form stands out for its long half-life and stable biological activity, making it ideal for daily and consistent use in combination with D3 — particularly when the goal is holistic support for bone, vascular, and overall metabolic health.

🌿 Berberine
Berberine is one of the most studied natural molecules in modern metabolic medicine. Recent randomized studies and meta-analyses show that it can contribute to lowering fasting glucose, HbA1c, and insulin resistance, while also being associated with a reduction in body weight and waist circumference. Furthermore, an improvement in the lipid profile has been observed, with favorable changes in total cholesterol and triglycerides, supporting a more balanced cardiometabolic phenotype.
In individuals with fatty liver, improvements in liver enzymes and metabolic markers have been noted, while in women with polycystic ovary syndrome (PCOS), berberine has been associated with better insulin regulation and support for hormonal balance — always within the framework of combining with established therapeutic approaches. At the same time, data suggest that it can contribute to reducing inflammatory markers such as CRP and IL-6, an important factor as chronic low-grade inflammation is closely linked to obesity and metabolic dysfunction.
In simple terms, berberine does not only target the number on the scale but the very mechanism of metabolism — creating a "cleaner," metabolically favorable environment where the body can respond more effectively to proper nutrition and exercise.

🌿 Chromium Picolinate
Chromium picolinate is one of the most studied forms of chromium in relation to metabolic regulation. Recent randomized studies and meta-analyses show that it can contribute to lowering fasting glucose, HbA1c, and insulin resistance, while also being linked to favorable changes in body weight and lipid profile. There is also data supporting its potential contribution to reducing markers of chronic metabolic inflammation and improving metabolic and hormonal markers in women with polycystic ovary syndrome (PCOS).
Additionally, a recent meta-analysis suggests that supplementation with chromium picolinate may be associated with a reduction in fat mass in specific population groups. In simple terms, chromium picolinate — like berberine — does not only target the number on the scale but supports the metabolic mechanism itself, creating a more stable and favorable internal environment where the body can respond more effectively to proper nutrition and systematic exercise.

🌿 α-Lipoic Acid – 600 mg
α-Lipoic acid (ALA) is one of the most studied bioactive molecules in metabolic medicine, with strong scientific evidence in both glucose regulation and oxidative stress management. Recent randomized studies and meta-analyses show that it can contribute to lowering fasting glucose, HbA1c, and insulin resistance, while also being associated with a reduction in body weight, waist circumference, and even blood pressure. At the same time, favorable effects on the lipid profile are observed, enhancing the overall cardiometabolic footprint.
Beyond glycemic regulation, ALA has strong antioxidant activity, contributing to the reduction of chronic low-grade metabolic inflammation. It has also been evaluated in women with polycystic ovary syndrome (PCOS), where it has been associated with improved insulin sensitivity markers and metabolic function, and it is an established choice for supporting patients with diabetic polyneuropathy.
In simple terms, α-lipoic acid — like berberine and chromium picolinate — does not simply target weight but the metabolic mechanism itself, creating a "cleaner," biochemically balanced internal environment where the body can respond more effectively to diet, exercise, and overall metabolic restoration.

🌿 Myo-inositol & D-chiro-inositol
The combination of myo-inositol and D-chiro-inositol is one of the most well-documented natural interventions for women with polycystic ovary syndrome (PCOS, as it directly targets the underlying pathophysiological disorder: insulin resistance and ovarian signaling dysfunction. Recent clinical studies and meta-analyses show that their administration is associated with improved insulin sensitivity, regulation of the menstrual cycle, support for ovulation, and improved fertility markers, while in some cases positive effects on clinical pregnancy rates have also been recorded.
Their action, however, is not exclusively limited to PCOS. Data from studies in broader populations — including postmenopausal women — show that inositols can contribute to improving insulin resistance, lowering fasting glucose and triglycerides, supporting a more balanced metabolic phenotype. In simple terms, this is a biologically targeted combination that enhances metabolic and reproductive function, with scientific evidence and multi-level application.

🌿 EGCG (Epigallocatechin gallate)
EGCG, the most bioactive catechin of green tea, has been extensively studied for its effects on human metabolism. Clinical studies and meta-analyses show that its administration can be associated with a reduction in fasting glucose and HbA1c, as well as an improvement in insulin sensitivity, supporting more stable glycemic control. At the same time, favorable changes in the lipid profile have been recorded, enhancing the overall cardiometabolic footprint.
Furthermore, EGCG appears to positively affect energy expenditure and fatty acid oxidation, promoting the use of fat as fuel, especially when combined with a balanced diet and systematic exercise. Thus, it can be a scientifically proven option for supporting metabolism and gradual, sustainable body fat loss within a holistic weight management strategy.

🌿 L-Arginine & L-Citrulline
L-arginine and L-citrulline constitute one of the most well-documented combinations for supporting vascular function and erectile performance. Both amino acids are directly involved in the synthesis of nitric oxide (NO) — the primary vasodilator molecule that increases blood flow to tissues and supports normal erection.
L-citrulline is converted in the body into L-arginine, providing a more stable and prolonged increase in its plasma levels compared to the individual administration of arginine. The result is enhanced NO production and more effective relaxation of the smooth muscle fibers of the blood vessels. Clinical data show that their combination can contribute to the improvement of erectile function, increased endurance, and improved muscle perfusion ("pump"), making them a key pillar in formulas aimed at maximum vascular performance and normal male function.

🌿 Beet Root
Beet Root (Beta vulgaris) extract is one of the most well-documented natural ingredients for improving vascular function, endurance, and blood flow, through its high content of inorganic nitrates (NO₃⁻).

In the body, dietary nitrates follow the well-known metabolic pathway nitrate → nitrite → nitric oxide (NO). Nitric oxide is a powerful vasodilator molecule that relaxes the smooth muscles of blood vessels, improves vascular elasticity, and enhances blood flow to tissues — resulting in better oxygenation, reduced oxygen cost during exercise, and enhanced physical performance.

Beyond nitrates, beet extract is rich in betalains (betanin, vulgaxanthin) with antioxidant and anti-inflammatory properties, as well as betaine (trimethylglycine) which supports normal liver function and homocysteine metabolism.

The dosage of 2500 mg represents a high potency content, designed for substantial nitrate delivery and effective contribution to overall vascular and energy health.

Benefits (Ingredient Benefits)

• Enhances nitric oxide (NO) production
• Improves vascular elasticity and blood flow
• Supports normal blood pressure
• Increases physical endurance and reduces exercise-induced fatigue
• Improves tissue and muscle oxygenation
• Antioxidant and anti-inflammatory action (betalains)

Supports liver function (betaine)

🌿 Tribulus terrestris
Tribulus terrestris has been evaluated in extensive clinical trials and systematic reviews for its contribution to sexual function, particularly in men with erectile dysfunction. According to a meta-analysis of randomized studies, its supplementation was associated with a significant improvement in IIEF-5 and IIEF-15 scores compared to placebo, suggesting a positive effect on erection quality and overall sexual performance. These data reinforce its role as a herbal option with clinical documentation in the field of male sexual health.
Additionally, clinical data from athletic or physically active populations show that Tribulus may be associated with improvements in physical performance indicators, such as muscle strength, endurance, and reduction in perceived fatigue. Thus, in addition to sexual function, it also contributes to the overall feeling of vitality and physical performance, making it a multifaceted ingredient in formulas that aim at both sexual and physical enhancement for men.

🌿 Maca (Lepidium meyenii)
Maca has been evaluated in men for both sexual function and energy and physical performance, with data from human studies supporting its multi-level action. Clinical trials in healthy adult men showed that its supplementation was associated with an improvement in physical performance and perceived endurance, translating into increased exercise capacity and overall daily activity. The same data also record positive changes in indicators of sexual function and satisfaction.
In studies using assessment tools such as the IIEF-5 and the Satisfaction Profile (SAT-P), Maca use was associated with a statistically significant improvement in erectile function and sexual satisfaction compared to placebo. These observations highlight that Maca can support not only sexual desire and satisfaction but also functional performance that affects the overall experience and male vitality, combining energetic and sexual benefits in a comprehensive framework of well-being.

🌿 Kaempferia parviflora (Black Ginger)
Kaempferia parviflora (Black Ginger) is a specialized herbal extract that has been evaluated in men for its contribution to erectile function and sexual performance. Clinical data show that its daily use is associated with an improvement in erectile function scores (IIEF), as well as an increase in sexual satisfaction and the overall quality of the sexual experience compared to placebo. Its action is attributed to its positive effect on vascular response and improved blood flow, factors crucial for normal and effective erection.
Overall, Black Ginger emerges as a modern, targeted herbal ingredient that supports male vitality, erectile performance, and sexual confidence. Integrated into a comprehensive male performance formula, it functionally contributes to improving the sexual experience and overall energy status.

🌿 Melatonin
Melatonin is a natural hormone that regulates the circadian rhythm and the sleep-wake cycle. A meta-analysis of randomized clinical trials in individuals with disturbed sleep shows that its supplementary administration can reduce sleep onset latency and increase total sleep duration, contributing to more stable and quality sleep. Deeper and sufficient sleep acts as a foundation for higher daily energy, better concentration, and a more balanced mood.
Furthermore, a recent systematic review and meta-analysis of randomized trials indicate that melatonin may have beneficial effects on metabolic and cardiometabolic markers, including improvements in lipid profiles, blood pressure, oxidative stress, and inflammation. In simple terms, melatonin not only supports sleep but can also contribute to a more balanced internal environment, enhancing overall well-being and preparing the body to respond effectively to daily demands.

🌿 Magnesium Bisglycinate
Magnesium bisglycinate is one of the most well-tolerated and bioavailable forms of magnesium. Clinical studies show that its daily intake may be associated with improved sleep quality and reduced severity of insomnia symptoms in adults with sleep difficulties. By supporting nervous relaxation and regulating mechanisms related to the circadian rhythm, it contributes to a smoother transition from wakefulness to nocturnal rest, helping the body "disconnect" from the day's overstimulation.
Additionally, magnesium plays a crucial role in muscle relaxation and the physiological stress response, promoting a more complete sleep experience and better morning recovery. Furthermore, its supplementary administration has been associated with a reduction in systolic and diastolic blood pressure, particularly in individuals with elevated levels, supporting vascular relaxation. There is also data indicating that adequate magnesium intake can contribute to improving symptoms of depression and psychological distress, possibly through the regulation of neurotransmitter mechanisms and the reduction of nervous overstimulation.

🌿 Glycine
Glycine is a natural amino acid with a documented contribution to sleep quality and nocturnal recovery. Clinical studies in individuals with sleep difficulties show that taking glycine before bedtime can improve subjective and objective sleep quality, reduce sleep onset latency, and be associated with better morning alertness and reduced feelings of fatigue the next day. These results were recorded through both questionnaires and physiological measurements.
At a mechanistic level, glycine appears to promote vasodilation and support the physiological drop in body temperature before sleep, through interaction with NMDA receptors in the hypothalamus — a process that facilitates the transition to a sleep state. At the same time, there is evidence that it can contribute to muscle recovery and improved physical performance after exercise, enhancing both quality rest and overall daily functionality.

🌿 L-theanine
L-theanine is a natural amino acid that has been studied for its contribution to relaxation and improving sleep quality. Clinical data show that it can reduce nocturnal awakenings and enhance the overall recovery experience, while also being associated with a reduction in perceived anxious arousal and an increase in the feeling of calmness. These effects make it particularly useful in the pre-sleep phase, as it helps the nervous system transition more smoothly from the day's tension to nocturnal relaxation.
These actions appear to be linked to the regulation of neurotransmitter pathways associated with relaxation and the circadian rhythm, without causing daytime sleepiness or a "heavy" feeling the next morning. In simple terms, L-theanine helps the mind calm down naturally, supporting a gentler transition into sleep and a more qualitative, restful night.

🌿 GABA (γ-Aminobutyric Acid)
GABA is the main inhibitory neurotransmitter of the central nervous system and plays a crucial role in regulating nervous excitement. Clinical data show that its supplementary intake can facilitate sleep onset, reduce anxiety levels, and enhance the feeling of calmness, contributing to a smoother and more restful experience of nocturnal rest. Its action through GABA-A receptors supports the physiological reduction of neural activity, creating the conditions for the transition from wakefulness to relaxation.
Furthermore, newer studies indicate that GABA can enhance physiological processes related to sleep quality and overall well-being, possibly through its effect on neural circuits that regulate the circadian rhythm and nocturnal recovery. In simple terms, it acts as a "natural relaxation switch," helping the nervous system de-stress from the day's demands and prepare for a calm and deep sleep.

🌿 Valerian (Valeriana officinalis)
Valerian is a herbal extract with documented effects on relaxation and sleep support. Clinical studies in adults with sleep disorders show that its use is associated with improved sleep quality, faster sleep onset, and a greater overall feeling of rest, accompanied by a reduction in nocturnal nervous tension. Participants reported an increased sense of calmness and fewer sleep interruptions, highlighting its ability to facilitate a natural and smooth transition to nocturnal rest.
Furthermore, a systematic review and meta-analysis of randomized studies confirm that supplementary administration of valerian is associated with a statistically significant improvement in subjective sleep quality indicators compared to non-use. This data reinforces its position as a natural and well-tolerated aid for those seeking more stable, deep, and rejuvenating sleep, making it an important pillar in comprehensive formulas aimed at overall evening relaxation and well-being.

Krill oil is emerging as one of the most comprehensive and bioactive forms of omega-3, with clinical data supporting its contribution to improving the lipid profile — reducing LDL cholesterol and triglycerides and increasing HDL. At the same time, it has been associated with better glucose regulation and a reduction in HbA1c, essentially reinforcing its role in promoting cardiometabolic health and overall metabolic balance.

Its action is not limited to the cardiovascular system. Newer clinical trials show that supplementation with krill oil can improve skin hydration, elasticity, and function, by reducing transepidermal water loss and enhancing the quality and appearance of the skin from the inside out. Simultaneously, in individuals with osteoarthritis, a significant reduction in joint pain and stiffness has been observed, confirming its broader anti-inflammatory and functional effect.

Furthermore, there is data supporting its possible contribution to improving symptoms of anxiety and depression, as well as enhancing cognitive functions, expanding the spectrum of its benefits beyond traditional metabolic contexts. In athletic populations, krill oil intake has been linked to an increase in the omega-3 to omega-6 index, a reduction in oxidative stress, an improvement in physical fitness and muscle performance, as well as better choline replenishment after intense exercise.

Overall, krill oil is not just another source of omega-3. The combination of its phospholipid form, natural astaxanthin, and multi-level clinical evidence makes it a premium, scientifically supported choice for those seeking cardiometabolic protection, improved performance, and holistic health support.